Not sure if I would see much real benefit of what I consider a small gear change, now if they went to a minimum of 4:30 or 4:56 yes indeed.
Comparetively speaking all 9 of My Tundras had 5.7L motors that made 381hp/401Tq, 6 speed with OD trans and 4.30 Gears.
VS
2019 Ram 2500 with 6.4L making 410hp and 429Tq if I recall, with 3.73s and 8 speed auto.
Heres how I see it...
The Ram is more truck Period, the suspension is beefier and the way you load the trailer really doesnt make that big of a difference, it rides better when loaded and just feels better to tow in.
The Tundra on the other hand IMHO can easily step into the ring with the Ram 2500 gas burner with very few modifications, IE..Air bags being #1 on the list. However the Tundra was just a smaller truck despite having above average everything for a 1/2 Ton Rig and as long as the trailer brakes work as they should it will stop pretty much just as well as the 2500.
Now the Tundra with only a few less HP and TQ takes full advantage of it with the 4.30 gears because it felt more snappy and was quicker to get into the RPm's and this seemed to get moving maybe a bit faster than my new Ram...Think a pedal commander is in my future lol...
Now heres the key to this whole deal...
My SR5 Tundras with 5.7, Crew Cab with console and 4wd all ran about 42-45k but for 40k I can get a Ram 2500 which is a lot more truck for the money and who cares if it's not as snappy out of the hole with a 10k lb load on it... So far as longevity is concerned all of my 9 Tundras pulled loads in excess of their rated capacity and all except the most recent that a tree fell on hit 80-100k b4 I traded them in and none ever had motor, rear end or transmission issues.. But why chance it, spend less money, get a Dodge 2500 and know your covered.