I know there is the obsession in diesel circles over fuel additives. The bottom line to me on any of them, is do the benefits outweigh the cost and inconvenience of adding it, and having it leak in the bed of your pickup.
Personally, I have a 2000 Ford F-450 with a 7.3 powerstroke with 336,000 miles on it. It has never had a fuel additive, just straight diesel except when I store it to keep alga growth down. Its on the original fuel pump, but it has had all new injectors which is typical for this motor, and run on OEM fuel filters. I did have the lift pump die as the fuel tank rusted out and clogged it with rust, not sure an additive would have helped there.
I also had a 2011 BMW 335D, that I did run some cetane booster. In houston we are in a non-clean air atainment area so all of our diesel is 48 cetane min, most of the country is 40. The 335D required 50, and ran more smoothly when I used opti-lube
On my 2019 Ram 3500 HO, I have run additives as possible peace of mind/protection against CP4 failure. It makes no difference on my regen cycle, the engine runs a bit smoother, and my wallet is lighter and my bed smells like additive. The the cummins inline-6 is no where close to the smoothness of my former bmw's diesel inline-6.
Constant/Frequent active regen's are due to poor combustion when the engine is too cold thus generating above average amounts of smoke (also more fuel dilution). The problem is especially bad when idling for extended periods (big problem on school busses with the 6.7). The folks who are just daily driving these vehicles see constant regens because they don't put enough of a load on the engine to heat up the DPF to allow a passive regen. These trucks are optimized for heavy duty work, and poorly optimized for using it as a car and no load. When I'm towing, I might go 1000-1500+ miles before seeing one active regen, because the engine generates enough heat to do passive regens.. When I rarely drive without a trailer, its when I see frequent active regens 1 about every 15-20 hours of driving. Additives would only help with this by improving engine combustion. Raising the Cetane helps, but most don't increase it by more than 1-2 points, the higher the cetane the easier it is to achieve complete fuel combustion meaning less soot, and less need for DPF regens.