It's not at all detrimental to the engine or any other components. In fact it is good for the turbo and will save your breaks. I wish there was an option from the factory to remember the last state of the EB so you didn't need to turn it on each time manually.
Calibrated Power's tune turns on the EB automatically and remembers your setting, full or auto. You only use the EB switch if you want to turn it off. It's a great feature for those of us that want it on all the time.
With no tune you can fool the truck into keeping it on all the time.
Trick your truck into thinking a trailer is in tow.
Use a blank 7 pin RV plug and wire a 12 ohm 8-10 watt resistor to the trailer brake and ground wire slots.
The Rear Park sensors will be disabled.
The Exhaust Brake will always be "On"
Sometimes when restarting a truck that has been off for a while, the EB will be "off". Just push EB button to turn back "on"
The towing mileage can be reset to zero anytime.