As has been said by a few I only lockout 6th if I'm towing up steep grades or through hilly/windy conditions or if the truck seems to be hunting for a gear. I don't see the point in locking out an OD gear, especially while the truck is in tow/haul mode. These trucks have all sorts of protections in them by default, so unless you're running tuned/deleted I say let her eat.
As for the EGT temps being high, I can't see them getting high enough to be anywhere close to an issue on these newer trucks. These newer blocks are much stronger than the old blocks and can easily withstand much higher EGTs, not to mention the fact that you do want some EGT heat to keep the DPF "lit" as it will help with passive regen. You can lower it but the system is just gonna have to dump fuel and heat it after the fact so may as well get the energy from it by working the engine.
Again, if you're going through mountains, steep grades, very hilly terrain, or around town and your truck is at all hunting, then lock out 6th, hell I lockout 5th sometimes depending on where I'm at. I just don't personally see the need.
That said, I also notice a loss of MPG by 1-2 when I lockout 6th unnecessarily. It most likely has something to do with the fact I'm running 37s, but I'll take it.