I did a bit of research before buying my 6.4, what I found is that most the motors with lifter and/or cam failures had more to do with long idle hours, infrequent oil changes and the like. Keep your oil fresh, idle hours low and you should be fine.
I personally think MDS is a gimmick to get .01% better to meet CAFE standard numbers, but it shouldn’t really hurt anything… at least in its latest implementations.
At least we don’t need to worry about the stupid auto start stop. That system makes 0% sense to me in terms of motor longevity. Sure it’ll save $60 a year on fuel… but at what cost of a starter, needing a second battery that goes bad, etc. in my Jeep I went thorough 4 sets of batteries under the 3 year/36,000 mile warranty with a 5th going bad when I traded in for the Ram.