Biodiesel has been around for quite a while now, and the product became more consistent in the last 10-15 years. The main problem with running B20 is that it has a cleaning action, in both tank and anywhere else, so when starting to use it you will need to watch the filter. They suggest changing the filter at a shorter interval to cover this, but I'd recommend changing it after just a few thousand miles the first time once you begin to run B20.
R99, Renewable Diesel, is a relatively new product. Biodiesel has largely been made by smaller plants, some make 3-5 million gallons a year, some 15 or 20 million, generally run by smaller private companies though some by larger feedstock companies. Renewable is coming on line in much larger plants in the gulf coast or CA or PA, 500-750 million gallon per year capacity, and owned by large corporations. It is a better product in that it has better cold pour and should have more consistency batch to batch.
For decades people driving diesels have said "Biodiesel is great, my truck runs quieter". It is generally true, the lubricity of biofuels is greater than ULSD. Running a diesel on used cooking oil also quiets it, but doesn't mean it's doing the engine any good. IMO it doesn't mean it is better. Yes, lubricity is a good thing, but our modern engines are designed to run on ULSD so to me it isn't a factor. Also the "burns cleaner" claim is true environmentally, but doesn't mean it burns cleaner in your engine.
I'm not anti biodiesel or renewable diesel, actually work indirectly in the industry and totally support those fuels. I would run B5 in my truck but not B20, and need to learn more about R99 before I'd run it.
