Just Did around a 700 mile trip to Canada pulling a 28 foot around 6700 lb travel trailer, lots of mountains. I have the 3.73 gearing and now 5800 total miles on the meter. The lyometer is right at 8.4 to 8.6 mpg in mountainous driving. Around 45 to 50% of my mileage is towing. The rest is transfer station, light off roading on Nat Forest roads, occasional runs to get heavy stuff. I live in the mountains and seldom do any on the flat mileage runs under 3500 feet. I usually get 15 to 17 mpg WITHOUT the trailer mix of highway local driving. The truck HATES city driving for good mpg, best mileage is around 60 to 65 mph steady flat runs hitting 17 and change mpg's. It is really too much of a beast to be a daily driver imho. I was fine with 1500's as a daily driver, but this thing crosses lines...literally in parking lots and in other ways, turns on a football field, no dimes. It likes the open road. I have a Jeep Renegade as a daily driver. I has been a pleasant surprise...
I've had my 2500 since early March and the engine gets better over time. The rpms love 2600 to about 3300 rpm driving/towing and it purrs in that range on cruise control 65 mph to 70 mph mostly flat runs towing. It will kick up to 4500 occasionally in cruise and hold speed on most hills in tow/haul and go to 5000 plus rpms if I step on it. Under some circumstances like a long steep uphill, i'll get a roar with the 6.4 that appears to be the cooling fan. I did hear that on the TFL Trucks video run up the Ike on a fully loaded 6.4 with 3.73 gearing. The engine is still evolving and getting smoother over time I am noticing, seems like mileage is slightly improving also. I actually expected worse mileage than I'm getting and am very surprised how well it competes with the 1500's mpg wise. Overall its not as good, but is surprisingly closer than I certainly expected. I've done some exact tracking of mileage earlier and it was within .4 of the lyometer on the bad side. As I get more mileage on the truck I'll check again here on a trip.
Having come off a 2021 1500 with the 5.7 and a 3.21 (It wasn't up to the new trailer even though within specs) AND a 2015 5.7 with 3.92, I can say that the towing mileage is virtually identical for all three trucks with the edge going to the 2500 with the 6.4 towing the same trailer. With the 1500's, on the 2021, the 8 speed transmission basically compensated for the different gearing (3.21) but tows approximately the same with the tranny working harder with the 3.21 and a bit less so in the 3.92 gears. A surpisingly similar tow. I'd give the edge to the 3.92 gearing on a 1500 towing as I occasionally would see 9 mpg with that set up, but not for long on the lyometer and with a smaller 22 foot trailer at 5500 lbs. Not with this 28 foot trailer at 6700 lbs.