Having lifted, leveled, and remained stock on various trucks throughout the years, my experience is that yes bringing the front end up does impact fuel efficiency. There are thousands of internet posts and thread with the same result. How severely it is impacted by the alteration varies from truck to truck, and of course the amount of adjustment. E.G. : leveling vs 4" lift, or 35" tires vs 40" tires or any combination of changes.
Speaking of tires. Yes, larger tires will typically impact efficiency too. It's especially noticeable if you're not adjusting the computer for the bigger size, since you're logging less miles than you're actually driving. As a result you aren't getting an accurate calculation (by hand or computer). Bigger tires will usually also added weight, and rotational resistance which will have a negative impact.
Every modification you make to your truck has the potential to impact efficiency. Some more than others, of course. That said, it's been widely established that lifts and/or tires hurt fuel efficiency. That's not to say it's an absolute so there are exceptions, but it has been verified a posteriori.