My 04 2500 did me well for 480,000 miles. Towed my 7000 lb trailer and got 19-20 miles to the gallon empty running around the Rocky Mountains in my sales job. I sold it to a friend in New York and it is still going strong. When I decided on a new truck, I wanted it to possibly be my last/greatest truck so I got everything on it I could think of. It is a loaded 3500 Bighorn HO with the factory air ride. I wanted the most durable setup I could order and poured over every item, ad nauseum. I have 39,000 miles on it and couldn't be much happier. After rowing the NV5600 tranny all those miles, I decided on going automatic and opted for the extra dough an the Aisin and HO combo. I was worried about the harsh ride as much of my driving is empty but that concern has left the building. Empty, I run 60 lbs in the front and 50 lbs in the back tires and I have to say the ride is very similar if not slightly better than my old 2500.
I'm happy with the Aisin and maintenance isn't much of a concern. There is a drain plug on the pan and Mobil tranny oil is available for less than $5 a quart. The HO engine pulls strong, tranny shifts fine, big rear end on leaf springs and air pulls my trailer so well, I have to look back to make sure it is still there. No regrets spending the extra money and getting the 3500.