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Tons of posts and threads on here about this. Many of us are. Check out the search bar or dig into the wheel/tire subforum deeper.
The truck handles it just fine. You will probably lose some mpg around town probably not effected on highway
You will lose some mechanical advantage by effectively making your gear ratio higher (numerically lower) so, yes the transmission will downshift sooner.
If you change tire size, you’ll want to recalibrate your truck for the new tire size. This will make sure your transmission shifts stay where they need to. There are also good threads on this subject.