I've got Lane Assist. I don't think it will do what you are thinking about. I've found Lane Assist on our 2022 3500 to be too much, too late. It will not keep the truck centered in the lane (at least ours doesn't). If you get too close to the edge, it will tend to turn you back to the other side of the lane, and continue an oscillation. Also, it will disengage without frequent steering input on the wheel. It would be very useful for preventing an inadvertent lane departure, but, IMO, doesn't reduce the "stress" of driving down a long stretch of interstate.
You can set the timing and feedback strength of Lane Assist. I have mine set to "early" and "light", but it still doesn't keep the truck centered in the lane or reduce the need for steering input. When I'm pulling our 5th wheel, I turn it off as it would tend to introduce some sway into the system from the back and forth feedback.
I wouldn't go through too much trouble or expense to add it.
If others are having a better experience than I am, I would appreciate tips I might not have tried.
Now, Adaptive Cruise Control, on the other hand, is fantastic. I've pulled a 5th wheel through the 100 miles of Salt Lake rush hour traffic without touching the brake or the fuel pedal.