This is what I've experienced with a 2022 Laramie 6.4 Hemi, 4.10, CC LB:-
7.5-10 around town, unloaded
15-17 on the highway (unloaded)
9.5-14 on the highway pulling a 7x14 cargo trailer (overall height 9.5', about 5000 loaded).
My highway towing mileage varies quite a bit depending on conditions (speed, cross winds, hills).
In general, it's probably pretty heavy on gas compared to a Cummins, but this is offset by initial acquisition cost of vehicle (roughly $10K less); price at the pump ($2.89 vs $4.69 today in St. Louis), no DEF, MUCH cheaper general maintenance costs, etc etc.
BUT - the Cummins is the way to go if you're mostly towing "heavy" on the highway.