On the 1,117 mile trip home with my new 2500 SO 68RFE I saw 20.71 highway, just me, doing whatever the speed limit was between Iowa and New Mexico & on cruise control vast majority of the trip. Over the next few fillups I've seen in the 14-15 range in town. The Road Trip app shows an average mpg of 15.8 over 3,417 total miles. Probably around 1,600 of this is unloaded highway, 993 of towing (primarily interstate) on a 1,500 mile recent trip (13.52 mpg on that) and the rest city.
The 993 trailer towing amount is from the trailer mileage function, so I'm assuming that's pretty accurate.