I'm going the opposite direction but have alot of towing on my 1500. My 2014 1500 has the 8 speed and 3.92 gears. It got 20 mpg on the stock tires (Goodyears) but as soon as I upgraded to an actual truck tire, mileage dropped to about 16 mpg hiway. Pulling my 14' aluminum trailer drops me to 12 mpg. Pulling my 20' tilt deck with anything on it puts me in the 10-12 range and towing my 28' toy hauler is 8-10. 72 mph is the max that I tow at and 65-70 mph seems to be the sweet spot where the truck is happy when pulling a moderate load.
My advice would be to stick with the 3/4 ton unless you really want the convenience of the smaller truck or the slightly better ride quality.
The 1500s are way under sprung in the rear and a coil upgrade or airbags are needed to reduce squat, even on a lightly loaded trailer. In my case I did springs, bags and heavier tires. These things helped towing immensely but also hurty unloaded ride quality. The '19 2500 that I test drove rode better than my 1500 does.
My experience with a 28 foot travel trailer at 6700 lbs and mileage on a 1500 is the same running 8 to 9 here in MT consistently and having had both a 3.92 rear end (2015 Outdoorsman) and a 3.21 (2021 Big Horn) they are very little different with the 3.92 maybe doing a very slight bit better. Those two got there differently with the 3.21 doing it with transmission and the 3.92 doing it more with the gearing, but not a substantive difference.
New 2022 Laramie 6.4 Hemi 2500: I actually get approximately the same gas mileage with my 2022 maybe a tad better in my 2500 towing the trailer. I was surprised. My first towing mpg on a 300 ish mile run with one low pass and a few 6% runs was 8.7 and I was pleasantly surprised with this. AND this is with an unbroken in 1100 mile new 2500. Now for running around town, I definitely suffer a bit vs a 1500 on mpg but not as much as I had thought I would.
Now, as far as comfort goes? The 1500's are noticeably more comfortable, easier to get into, easier to park. The new 2500's are very comfortable and not much different inside, but there is NEVER any doubt you are in a truck daily driving. In a 1500, even the old 2015, you could be in a luxury SUV and forget you are driving a TRUCK. A whole lot more stiffness and bounce in a 2500. The 1500 has a much bigger back seat area, like four inches wide. We put big dogs in the back flat floor down and noticed. You will get a couple mpg better gas mileage between a 5.7 and a 6.4 daily driving maybe more depending upon your drive (highway vs urban) and now days an extra 10% plus in gas mileage is nothing to sneeze at in relation to your pocketbook.
Now if you are going to tow, a 1500 with a 6K up travel trailer and all the accoutrement associated, you will NEVER forget you have the trailer on the back and upon occasion and certain environmental and road conditions the trailer may argue with the truck on just exactly who is in charge with you along for the ride for a few seconds. The 2500 is always in charge is my observation and I am able to relax much more over a six hour or more day of towing thereby giving a peace mind that is much better at the end of the day.
I have a Jeep Renegade as a daily driver as it gets roughly double MPG of any of the Rams I've had. I am fortunate that I can dedicate the RAMs to trailer towing, transfer station runs and project support at Home Depot/Lowes etc. I do around 8K a year on the truck and maybe 10K on the Renegade. Hey, it gets me the low mileage discount on my insurance... And, of interest, I have been offered what I paid for the Renegade (18.5K) new after three years and 25K miles from my dealership... Strange world.